Altitude sickness

Take the person to a lower altitude as quickly and safely as possible.

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Altitude sickness occurs when people at a high altitude do not have enough oxygen in their blood because the air pressure is too low. As altitude increases, the air becomes thinner and less oxygen is inhaled with each breath. The term altitude sickness includes acute mountain sickness, high altitude pulmonary oedema (affecting the lungs and breathing) and high-altitude cerebral oedema (affecting the brain, behaviour and alertness). These illnesses are also called AMS, HAPE and HACE  respectfully. Individuals most affected by altitude sicknesses are those who travel to a high altitude quickly (e.g., tourists), especially if they have pre-existing medical conditions. However, trained mountaineers can also develop symptoms when they reach very high altitudes, such as in the Himalaya region.

 

Guidelines

  • People experiencing AMS, HACE and HAPE should stop their ascent immediately and start to descend safely, with support, until their symptoms lessen. **
  • If the person has prescribed medication for altitude sickness with them (such as acetazolamide or dexamethasone), the first aid provider may assist them in taking it based on the label instructions. *
  • Where local laws, regulations or protocols permit, specially trained first aid providers may give medications (such as acetazolamide or dexamethasone) to individuals experiencing altitude sickness. *
  • For first aid providers trained in its use, oxygen may be administered to individuals experiencing AMS, HACE and HAPE. *

Good practice points

  • People experiencing altitude sicknesses should be kept from getting cold or overheated.
  • Gradual ascent to higher altitudes may be a more effective method of prevention than a fast ascent.
  • Adequate hydration should be maintained (though not forced). The person should drink regularly (every 20-30 minutes) and enough (more than they would normally drink).

Guideline classifications explained

Chain of survival behaviours

Prevent and prepare
  • Check how to access local emergency services and pack appropriate signals and contact details when going to high altitudes.
  • Ensure you have the right equipment with you to make a safe descent.
  • Eat high-energy foods and drink high-calorie drinks, as well as water, to prevent dehydration.
  • Ensure someone knows the route you plan to take if you are venturing to a remote place, and when you expect to return.
  • Avoid alcohol.
Early recognition

People may start to experience symptoms around 2400 m (roughly 8000 feet). Twenty-five per cent of travellers experience AMS above 3500m (11,483 feet), with 50 per cent experiencing it above 6000m (19,685 feet). Be aware of the signs of altitude sickness if travelling above this altitude (Hackett & Shlim, 2019).

Several altitude sickness diagnostic-scoring systems exist. The Lake Louise Criteria for Altitude Sickness (Roach et al., 2018) are as follows:

Acute mountain sickness

If the person chooses to remain at a certain altitude, AMS may improve with rest, hydration and medication. However, the symptoms will improve faster by descending to a lower altitude. There is also the risk that AMS will progress to HAPE or HACE.

  • Headache and at least one of the following symptoms: fatigue or weakness; dizziness or light-headedness; gastrointestinal symptoms (nausea or vomiting, loss of appetite); difficulty sleeping; shortness of breath.
High-altitude pulmonary oedema

HAPE is when fluid collects in the lungs (pulmonary oedema) and causes extreme shortness of breath. It is life-threatening and requires immediate, safe descent.

  • At least two of the following symptoms: difficulty breathing while resting; coughing; weakness or decreased physical performance; chest tightness or congestion and;
  • At least two of the following signs: crackling or wheezing heard in one or both lungs when breathing; bluish colouring to the skin, lips and fingers; rapid breathing and elevated heart rate.
High-altitude cerebral oedema

HACE is when fluid collects on the brain, causing confusion, coma, and if untreated, death. It is life-threatening and requires immediate, safe descent.

  • Change in responsiveness, behaviour, normal movement or coordination in a person either with or without acute mountain sickness.
First aid steps
  1. Help the person move to a lower altitude as quickly and safely as possible. Encourage them to drink water.
  2. If the person has prescribed medication for altitude sickness, help them take it.
  3. Have the person rest at a lower altitude until their symptoms resolve. If local regulations permit, and you are trained to do so, administer oxygen to the person. You may do this upon arrival at a lower altitude, or if necessary while descending with the person.
  4. Access EMS if the person’s condition doesn’t improve.

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NOTE

Monitor the person’s temperature to ensure they do not get too cold or too hot. See Hypothermia or Hyperthermia.

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Access Help
  • Access help if the person is unable to descend on their own and it is unsafe for other group members to transport them to a lower altitude. Help may take many forms, including other hikers, search and rescue, formal evacuation teams or military assistance.
  • Access EMS if the person’s condition does not improve.
Recovery
  • If a person with AMS is asymptomatic, they may continue to ascend. They should monitor themselves for signs and symptoms of AMS, HAPE and HACE.
  • Once descended to a lower altitude, a person with HAPE or HACE should not re-ascend until their symptoms have resolved and they have been examined by a medical professional.

Education considerations

Context considerations
  • Altitude sickness can affect a variety of groups ranging from hikers, climbers, seasonal employees and tourists. There are many towns and cities across the world that are at a high altitude. We advise first aid programme developers to work with local authorities and tour companies to publicly display educational material informing people of the signs and symptoms, the importance of staying hydrated and how to get help.
  • Refer to local guidelines and include any context-specific information in the programme.
  • Engage local medical experts, mountain rescue groups and tour operators when developing content for this topic.
  • Follow local laws and regulations concerning helping people with prescribed medications and administering oxygen.
  • Use posters and other media in high altitude areas with tourists to raise their awareness of altitude sickness.
Facilitation tips
  • Emphasise how to prevent and recognise the symptoms of altitude sicknesses as often, the person affected may not realise they have it.
  • Use visual materials (pictures and videos) to illustrate signs and symptoms of the different types of illness that high altitudes can incur.
Learning connections
  • Being at high altitudes can cause someone to Feel faint; make connections to this topic.
  • Symptoms of AMS may appear similar to those of Dehydration.

Scientific foundation

Systematic review

The Centre for Evidence-Based Practice (CEBaP) developed an evidence summary on the practice of descending if someone is experiencing altitude sickness and a summary about drinking adequate amounts of water as a protective factor for altitude sickness. A Cochrane systematic review looked at pharmacological interventions for altitude sickness, including oxygen provision.

Descent

One study showed that 193 mbar (equal to descending 2250 m or 7382 feet) resulted in a statistically significant decrease in the clinical score of mountain sickness and AMS cerebral score immediately after treatment, compared to resting at ambient pressure (i.e., not descending). In addition, this study showed that 20 mbar (equal to descending 250 m or 820 feet) resulted in a statistically significant decrease in the AMS cerebral score immediately after treatment, compared to resting at ambient pressure (i.e. not descending). However, the study could not demonstrate a statistically significant decrease in the clinical score and AMS cerebral score 12 hours after descending 193 or 20 mbar. The evidence is very low certainty, and results cannot be considered precise due to limited sample size and lack of data.

Oxygen

The Cochrane systematic review identified one small study with 13 participants about the use of oxygen (Simancas-Racines 2018). The low-quality study describes the improvement in AMS with the use of three litres of oxygen per minute for ten minutes. It found that treatment with oxygen significantly improved the symptoms of AMS and improved the person’s oxygenation.

Other medication interventions

The Cochrane systematic review also identified studies on the use of medicines to relieve the symptoms of AMS. Studies related to administration of medicines found some benefits in terms of reduction of symptoms with the use of acetazolamide (two studies, 25 participants, low-certainty evidence), and dexamethasone (one study, 35 participants, moderate-certainty evidence), without an increase in side effects. The effects from two additional trials comparing gabapentin with placebo and magnesium with placebo on symptom severity at the end of treatment were uncertain (low-certainty evidence). 

Hydration

Five observational studies were identified, looking at several risks or protective factors for AMS, including water intake. A statistically significant increased risk of AMS in case of low water intake compared to higher water intake could not be demonstrated in three studies, including two studies that conducted a multivariate analysis. Two other studies did find a significantly increased risk of AMS in case of low water intake (compared to high water intake), but these studies did not correct for confounding factors in a multivariate analysis. Evidence is of very low certainty and results cannot be considered precise due to limited sample size or a low number of events and lack of data. 

Non-systematic review

Based on a small randomised controlled trial with 34 healthy mountaineers, gradual ascent to higher altitudes seemed a more effective method of prevention than a fast ascent (Bloch, 2009).

References

Systematic reviews

Centre for Evidence-Based Practice, Belgian Red Cross-Flanders. (2020). Evidence summary Altitude sickness – Drinking fluids. Available from: https://www.cebap.org/knowledge-dissemination/first-aid-evidence-summaries/

Centre for Evidence-Based Practice, Belgian Red Cross-Flanders. (2020). Evidence summary Altitude sickness – Descent. Available from:
https://www.cebap.org/knowledge-dissemination/first-aid-evidence-summaries/

Simancas-Racines, D., Arevalo-Rodriguez, I., Osorio, D., Franco, J. V., Xu, Y., & Hidalgo, R. (2018). Interventions for treating acute high altitude illness. Cochrane Database of Systematic Reviews, (6). Retrieved from https://pubmed.ncbi.nlm.nih.gov/29959871/

Non-systematic reviews

Bloch, K. E., Turk, A. J., Maggiorini, M., Hess, T., Merz, T., Bosch, M. M., … & Schoch, O. D. (2009). Effect of ascent protocol on acute mountain sickness and success at Muztagh Ata, 7546 m. High altitude medicine & biology, 10(1), 25-32.

Hackett, P. H., & Shlim, D. R. (2019). Environmental Hazards & Other Noninfectious Health Risks. High Altitude Travel & Altitude Illness (3). Retrieved from https://wwwnc.cdc.gov/travel/yellowbook/2020/noninfectious-health-risks/high-altitude-travel-and-altitude-illness

Roach, R. C., Hackett, P. H., Oelz, O., Bärtsch, P., Luks, A. M., MacInnis, M. J., … & Lake Louise AMS Score Consensus Committee. (2018). The 2018 Lake Louise acute mountain sickness score. High altitude medicine & biology, 19 (1), 4-6. Retrieved from https://www.liebertpub.com/doi/pdfplus/10.1089/ham.2017.0164

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Published: 15 February 2021

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